Assessment of the foot pressure threshold may have promise as a simple and inexpensive method for detecting diabetic patients at risk for footulcers. It employed a qualitative research design, including both qualitative and quantitative data collection techniques to provide robust and trustworthy findings. To explore expectations of and reactions to the screening experience of patients with positive, negative, and intermediate results. Conclusion: The use of a prognostic test in patients perceived to be high risk for diabetes was associated with a modest but significant increase in the prescription of metformin and lifestyle interventions and a reduction in BMI. Received January 12, 1990. RESEARCH DESIGN AND METHODS. A higher PreDx score was significantly associated with metformin prescription (p=0.0003), lifestyle counseling (p=0.0099), and a lower BMI at follow-up (p=0.007). Development and validation of a model for predicting incident type 2 diabetes using quantitative clinical data and a Bayesian logistic model: A nationwide cohort and modeling study. We tested the effect of 32 mg/d RBX, a specific PKC [beta] inhibitor, on quantitative measures of DPN. OBJECTIVE—Evaluate type 2 diabetes susceptibility variants identified from genome-wide association studies in Hispanic Americans and African Americans from the Insulin Resistance Atherosclerosis Family Study (IRAS-FS) for association with quantitative measures of glucose homeostasis and determine their biological role in vivo. SNP rs4402960 was associated with alteration of the disposition index with the “risk” allele T, as determined from the GWA reports (3–6), at a comparable frequency compared with estimates from the European-derived populations and associated with reduced disposition index (P = 0.011) following an additive model (P = 0.0031). In recent years, great emphasis has been placed on the role of nonpharmacological self-management in the care of patients with diabetes. Background Type 2 Diabetes Mellitus (T2DM) is reported to affect one in 11 adults worldwide, with over 80% of T2DM patients residing in low-to-middle-income countries. These SNPs showed the strongest evidence of association in the dominant model (Supplemental Table 1A, which is detailed in the online appendix [available at http://dx.doi.org/10.2337/db07-1169]; P = 0.0010 and 0.0011, respectively) with an 18.1% average decrease corresponding to 151 pmol/l insulin in the genotypic mean for AIR associated with the presence of the “risk” alleles C. The next strongest association was also observed with AIR for rs7480010 (P = 0.0046) in a hypothetical gene (chromosome 11; LOC387761). RESULTS— Previously identified risk variants in cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 ( CDKAL1 ) were associated with reduced AIR ( P < 0.0046) in Hispanic Americans. journal = "Nutrition, Metabolism and Cardiovascular Diseases", Nutrition, Metabolism and Cardiovascular Diseases, https://doi.org/10.1016/j.numecd.2013.09.010. We report data for 20 placebo [PBO] and 20 RBX-treated patients ([ge]18 years old, type 1 or 2 diabetes, and HbA1c [le]11%) enrolled in a randomized, double-blind, single-site trial in the United States. RESEARCH DESIGN AND METHODS—Seventeen type 2 diabetes–associated single nucleotide polymorphisms (SNPs) were genotyped in 1,268 Hispanic- and 581 African-American participants from the IRAS-FS. DOI: 10.2337/db07-1169. Further, diabetes was often based on self-report and was not the primary outcome. 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